Consensus Statement Prolotherapy for Musculoskeletal Pain

Journal of Prolotherapy International Medical Editorial Board Consensus Statement on the Use of Prolotherapy for Musculoskeletal Pain

Ross Hauser, MD, et al. Journal of Prolotherapy international medical editorial board consensus statement on the use of prolotherapy for musculoskeletal pain. Journal of Prolotherapy. 2011;3(4):744-764.


The purpose of this paper is to explicate the theory, scientific evidence, methods, and applications for the procedure of Prolotherapy in the treatment of musculoskeletal pain. The example of Prolotherapy for knee osteoarthritis is used as an example as to why Prolotherapy should be used compared to other invasive therapies.

Goal of Prolotherapy

The goal of Prolotherapy is the resolution of pain and dysfunction and the optimizing of health by the individual regaining the ability to do activities of daily living and exercise. Once this is achieved, the individual will potentially no longer need medical care for pain and disability. When this goal is not possible, Prolotherapy aims to help improve one’s quality of life by diminishing pain and improving mobility, activities of daily living, and/or exercise.


Prolotherapy as defined in Webster’s Third New International Dictionary is “the rehabilitation of an incompetent structure, such as a ligament or tendon, by the induced proliferation of new cells.” Most Prolotherapy involves the injection of solutions at the fibro-osseous junctions or entheses, the point at which tendons and ligaments attach to the bone, to induce an inflammatory reaction. This induction of the inflammatory healing cascade initiates the regeneration and repair of the injured tissues in and around the joint, stabilizing and eliminating the sources of most musculoskeletal pain.* Prolotherapy can be an ideal treatment for chronic musculoskeletal pain caused by sprained, injured or torn tendons and/or ligaments in such conditions as joint instability, ligament laxity and tendinopathy including tendinosis; as well as other conditions such as enthesopathies and degenerative osteoarthritis involving the peripheral and spinal joints.

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