Ross Hauser, MD; Danielle Matias, PA-C; Demi Foster, APRN Part 1: An introduction to PRP treatments. The science PRP as an anti-inflammatory. Chronic inflammation from structural breakdown caused by knee instability. Platelet-rich plasma can provide key factors balancing proinflammatory and anti-inflammatory factors. PRP as an anti-inflammatory. Chronic inflammation from structural breakdown caused by knee instability. Platelet-rich plasma can provide key factors balancing proinflammatory and anti-inflammatory factors. Runaway, chronic inflammation destroys the extracellular matrix (ECM) in the osteoarthritic knee. Stopping extracellular matrix dilution is one of the healing factors in PRP. One of the characteristics of PRP is that it works … Continue reading Platelet Rich Plasma for Knee Osteoarthritis: When it works, when it does not work