Prolotherapy Research Shoulder Osteoarthritis, Tears and Chronic Pain Disorders

Many conditions can cause chronic shoulder pain, such as rotator cuff tears, frozen shoulder, osteoarthritis, impingement, and joint instability. In the paper below, our research team documented successful Prolotherapy treatments to the shoulder.

Prolotherapy Research Shoulder

The article in its entirety can be downloaded now as a PDF

A Retrospective Study on Hackett-Hemwall Dextrose Prolotherapy for Chronic Shoulder Pain at an Outpatient Charity Clinic in Rural Illinois

Hauser RA, Hauser MA. A Retrospective Study on Hackett-Hemwall Dextrose Prolotherapy for Chronic Shoulder Pain at an Outpatient Charity Clinic in Rural Illinois. Journal of Prolotherapy. 2009;1(4):205-216.


  • We studied a sample of 94 patients with an average of 53 months of unresolved shoulder pain that were treated quarterly with Prolotherapy.
  • An average of 20 months following their last Prolotherapy session, patients were contacted and asked numerous questions in regard to their levels of pain and a variety of physical and psychological symptoms, as well as activities of daily living, before and after their last Prolotherapy treatment.
  • The results of this study showed that patients had a statistically significant decline in their level of pain, stiffness, and crunching sensations (crepitation), to the p<.0000001 level with Prolotherapy, including the 39% of patients who were told by their medical doctors that there were no other treatment options for their pain and the twenty-one percent who were told that surgery was their only option.
  • Over 82% of all patients experienced improvements in sleep, exercise ability, anxiety, depression, and overall disability with Prolotherapy. Ninety-seven percent of patients received pain relief with Prolotherapy.

Conclusion: In this study, patients with chronic shoulder pain reported significant improvements in many clinically relevant parameters and overall quality of life after receiving Hackett-Hemwall dextrose Prolotherapy.

Shoulder Joint Instability

When it comes to seeking non-surgical options in the treatment of difficult to treat or chronic shoulder pain, patients frequently find themselves researching our injection treatments of Comprehensive Prolotherapy incorporating various treatments to include Stem Cell Therapy, Platelet Rich Plasma Therapy, and Dextrose Prolotherapy.

These injection techniques stimulate the repair of injured tissue and have been cited in the research as curative for chronic pain.

In the athletic patient, shoulder injuries, such as falls onto an outstretched hand, dislocations, or direct blows to the shoulder can cause damage both to the joint itself and the surrounding structures (i.e. ligaments and tendons). When these injuries don’t heal properly, patients can develop chronic shoulder pain that doesn’t seem to go away despite various methods of treatment.

For more specific articles related to your Shoulder Pain please see our library of articles:

Rotator Cuff Tear Alternatives To Surgery In this article we discuss the problem of initial rotator cuff tear and re-tears  caused by non-healing of the rotator cuff tendons and non-surgical options.

Rotator Cuff Tendinopathy – Tendinitis – Tendinosis In this article we discusses diagnosis and treatment of Rotator Cuff Tendinopathy. Treatments include conservative care and the emerging science of  biological augmentation (Platelet Rich Plasma Therapy and Stem Cell Therapy).

Bone Spurs in the shoulder A bone spur (more technically known as osteophyte) is an abnormal bony overgrowth that extends out from the normal bone. Bone spurs develop from underlying joint instability. See how our treatments handle shoulder instability and resulting bone spurs.

Slap Lesion Tears New research explored the many surgical options in the treatment of SLAP lesions, however, while there are many options, unfortunately the success rates of these surgeries are being called into question.

Shoulder Replacement Information In this article we will explore options and alternatives to Shoulder Joint Replacement and Reverse Total Shoulder Replacement.

Glenoid Labral Tears A discussion of injury to the glenoid labrum results in instability, dislocation and pain.

Frozen Shoulder – Adhesive Capsulitis Frozen shoulder, medically referred to as adhesive capsulitis, is a general term for a variety of causes of loss of motion in the shoulder. See how our treatments can help patients with this chronic condition.

Chronic Shoulder Dislocation and Instability In this article we will discuss that the main cause of chronic shoulder dislocations are chronic shoulder dislocations. This is not a play on words, treat and cure the chronic shoulder dislocation and you prevent future dislocations.

Shoulder Impingement Syndrome In this article, Ross Hauser, MD discusses treatments for shoulder impingement syndrome. In new research, doctors note that there are many treatments for shoulder impingement syndrome. Some work, some did not work as well, some worked best when combined with exercise (Movement).

Acromioclavicular joint arthrosis Acromioclavicular (AC) joint arthrosis can develop as a result of chronic shoulder dislocation or normal wear and tear in the aging patient with heavy shoulder rotational loads in sports or work.